Research Associate, Targeting the Clock in Metabolic Disease

Manchester, United Kingdom
£32,236 - £34,189 Per Annum (according to relevant experience)
22 Jan 2019
End of advertisement period
21 Feb 2019
Contract Type
Fixed Term
Full Time

Location : Oxford Road, Manchester
Closing Date : 21/02/2019
Salary : £32,236 - £34,189 Per Annum (according to relevant experience)
Employment Type : Fixed Term
Faculty / Organisational Unit : Biology, Medicine & Health
Division : Diabetes, Endocrinology & Gastroenterology
Hours Per week : Full Time
Contract Duration : ASAP until 31 January 2020

We are seeking a highly motivated, skilled and committed post-doctoral scientist to study the role of circadian clock in obesity-related inflammation and the development of metabolic disease. You will be joining a large, well-funded research group based within the brand-new AV Hill Building at University of Manchester. The post is funded by a MRC research grant, with the aim of identifying novel targets for therapeutic intervention in obesity and Type 2 Diabetes. Specifically, our recent work has revealed the clock protein REVERBα to be an important player in adipose tissue function, and the development of adipose tissue inflammation and insulin resistance that accompanies obesity. Work on the project has already identified key immune cell populations within the ‘safe-fat’ phenotype of the Reverbα-/- knockout. It is now critical to delineate mechanisms by which Reverbα influences adipose-immune cell interaction in health and disease states. This project benefits from novel transgenics allowing cell and tissue specific modulation of the clock, state-of-the-art flow cytometry, FACS, and single cell genomics techniques, as well as a novel technique for cell-specific recording of clock gene expression in vivo. You must hold (or shortly hold) a PhD in immunology, physiology, or related discipline. Experience with immune cell dynamics, flow cytometry, and FACS are essential. Experience in cell and molecular biology (gene/protein expression analyses, cell/tissue culture, transfection, viral mediated gene expression) and in vivo physiological assessment, and bioluminescence imaging are desirable. The position is available from February 2019 for 12 months.

The School is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The School holds a Bronze Award for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Name: Dr David Bechtold


Tel: 0161 275 5721

General enquiries:


Tel: 0161 275 4499

Technical support:


Tel: 0161 850 2004

This vacancy will close for applications at midnight on the closing date

Further Particulars