MASARYK UNIVERSITY

Postdoc and PhD position in Integrative Structural Biology of 3`UTRs

Location
Brno, Czech Republic
Posted
03 Dec 2018
End of advertisement period
31 Dec 2018
Ref
34686
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Permanent
Hours
Full Time

Research Group: RNA-based Regulation of Gene Expression

Research Group Leader: Peter Josef Lukavsky, Ph.D.

Project information:

The non-coding part of the genome vastly increased from worm to humans while the number of protein-coding genes remained constant. This expansion includes 3’UTRs of mRNAs with an average length of 1.2 kb in humans and functions in mRNA transport, translational control and mRNA decay. Despite the importance of 3’UTRs for spatial and temporal control of gene expression, the molecular basis of 3’UTR functions is largely unknown. We will determine complexes of 3’UTR signals with Staufen1 protein and the ribosome which regulate mRNA stability and control translation. Using integrative structural biology approaches, including NMR spectroscopy and cryo-EM, we will unravel the molecular basis of Staufen-mediated 3’UTR functions in posttranscriptional regulation of gene expression and thus provide new insights into how deregulation can lead to diseases such as cancer and neurodegeneration.

CEITEC is a vibrant work place with excellent colleagues and infrastructure for integrative structural biology including a Titan Krios and F20 as well as six high-field NMR instruments from 500 to 950 MHz. In addition, the historic city of Brno offers a lively atmosphere with many cultural, culinary and sportive possibilities.

Requirements:

We are looking for highly motivated researchers with a strong background or interest in structural biology who share our fascination for RNA/protein structure and function. Candidates should have experience in molecular biology, RNA/protein biochemistry and biophysics. Good communication and interpersonal skills and fluency in spoken and written English are required.

Employment Conditions:

Salary that will be based on the candidate`s qualifications and experience.

Please send application (including CV, short statement of research background / interests and the contact information of at least three references) by email to: peter.lukavsky@ceitec.muni.cz