Research Scientist

Location
Massachusetts, United States
Posted
27 Nov 2018
End of advertisement period
27 Jan 2019
Ref
16786
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Permanent
Hours
Full Time

Working at MIT offers opportunities, an environment, a culture – and benefits – that just aren’t found together anywhere else. If you’re curious, motivated, want to be part of a unique community, and help shape the future – then take a look at this opportunity.

RESEARCH SCIENTISTResearch Laboratory of Electronics (RLE), to design and build logic operation and memory systems in mammalian cells for therapeutic applications. The work consists of four parts -- finding disease sensors, finding effectors, building synthetic gene circuits using logic operation and memory systems, and testing combined synthetic gene circuits in animal disease models. Disease models include cardiovascular diseases and cancer. Responsibilities will include establishing in vitro disease models in mammalian cells; performing pooled library screening to identify disease sensors and effectors by using in vitro disease models; validating sensor or effector candidates from pooled library screening in in vitro and in vivo disease models; designing and building logic operation and memory systems that work in mammalian cells in viral vectors; testing synthetic gene circuits in mammalian cells by using viral vectors; designing and building combined synthetic gene circuits with sensors and effectors identified by screening in viral vectors; testing combined synthetic gene circuits in in vitro disease models by using viral vectors; optimizing viral vector delivery efficiency in animals; and testing combined synthetic gene circuits in animal disease models by using viral vectors. 

Job Requirements

REQUIRED: M.D. or Ph.D.in biology or related field; at least one year of postdoctoral work; extensive knowledge of molecular biology, CRISPR technologies, synthetic biology, and clinical medicine; standard molecular and cell biology skills including cloning methods, PCR methods, Western blot, ELISA, immunocytochemistry, and immunohistochemistry; experience with mammalian cell culture with various assay systems (both cell lines and primary cells), viral production, flow cytometry, pooled library screening using Next-Generation Sequencing, and animal experiments including microsurgeries. Job #16786

11/15/18

MIT is an equal employment opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, sex, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, ancestry, or national or ethnic origin.