UNIVERSITY OF MANCHESTER

Research Associate in Mitochrondrial Arrest Mechanisms

Location
Manchester, United Kingdom
Salary
£32,236 - £35,211 per annum according to experience
Posted
09 Nov 2018
End of advertisement period
10 Dec 2018
Ref
BM&H-13042
Contract Type
Fixed Term
Hours
Full Time

Location : Oxford Road, Manchester
Closing Date : 10/12/2018
Salary : £32,236 - £35,211 per annum according to experience
Employment Type : Fixed Term
Faculty / Organisational Unit : Biology, Medicine & Health
Division : Cardiovascular Sciences
Hours Per week : Full Time
Contract Duration : 01 Feburary 2019 until 31 January 2022

Obesity is a global health problem “Globesity” currently affecting over 650 million adults (WHO, 2017). Significantly, obesity is an independent risk factor for the development of cardiovascular disease and common precursor to type 2 diabetes. The focus of the Kitmitto group is the delineation of the pathophysiological structure-function remodelling events that develop in the ‘obese’ heart. We have already determined using a diet-induced model of obesity that there is a breakdown of the cardiomyocyte mitochondrial network, resulting in dysfunctional cardiac energetics and impaired contractility. The focus of this project will be to determine the molecular drivers of mitochondrial remodelling and identification of novel biomarkers of cardiac dysfunction. This is an exciting opportunity to join a multidisciplinary team, also working with Dr Elizabeth Cartwright and Professor Joy Wang, to make a major contribution to our understanding of the development of cardiac complications associated with obesity. By the identification of early patho-mechanistic remodelling events we aim to develop new approaches to patient treatment and to prevent disease progression.

You must have a PhD or equivalent in a bioscience related degree. Relevant experience in eukaryotic cell culture (including transfection techniques), immunochemical detection, and general molecular biology, biochemical and biomolecular analysis methods are essential. It would be highly advantageous if you have knowledge and practical experience of methods for measuring mitochondrial function. Experience of coordinating projects with small animal models (mice) would be desirable. Ideally, the candidate will also have practical experience of cardiac cell isolation and fluorescent microscopy techniques. While not essential, experience of methods for sample preparation for electron microscopy would be advantageous. The post holder should also be highly motivated, work independently and have excellent organisational, time-management and communication skills.

The School is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The School holds a Bronze Award for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit: https://www.bmh.manchester.ac.uk/about/equality/

Successful candidates may be subject to pre-employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing that screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place, and agree to take part in the process.

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Name: Dr Ashraf Kitmitto

Email: ashraf.kitmitto@manchester.ac.uk

Tel: 0161 306 4186

General enquiries:

Email: hrservices@manchester.ac.uk

Tel: 0161 275 4499

Technical support:

Email: universityofmanchester@helpmeapply.co.uk

Tel: 0161 850 2004

This vacancy will close for applications at midnight on the closing date

Further Particulars

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