Senior Research Associate in Nutritional and Epigenetic Epidemiology
Division/School Bristol Medical School
Contract type Fixed Term Contract
Working pattern Full time
Salary £37,345 per annum
Closing date for applications 06-Dec-2018
This post offers an excellent opportunity for a talented epigenetic epidemiologist to join the MRC Integrative Epidemiology Unit within the Department of Population Health Sciences in the Bristol Medical School, University of Bristol, one of the leading centres for Epidemiology in the UK.
The rising prevalence of obesity, cardiometabolic disease, asthma, osteoporosis and neurodevelopmental disorders over recent decades cannot be fully explained by genetic or adult lifestyle factors. Increasing evidence suggests early life exposure to environmental factors influences offspring health; therefore, maternal diet during pregnancy is a modifiable behaviour that could impact on maternal, neonatal and child health.
To advance the state-of-the-art, a European consortium called ALPHABET (“Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health ”) was formed to investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Members represent several prominent European longitudinal birth cohorts and studies including ALSPAC, Generation R, Southampton Women’s Survey, EDEN mother-child cohort study, The Polish Mother and Child Cohort, Lifeways Cross-Generation Cohort Study, the ROLO study and the PEARS study.
The post-holder will represent ALSPAC and lead consortium analysis of DN A methylation associations with dietary exposures and health outcomes and, where possible, investigate causal relationships using Mendelian randomization.
ALPHABET work at the University of Bristol is funded by the Biotechnology and Biological Sciences Research Council.
The successful applicant will have a PhD (or equivalent research experience) in Epigenetic Epidemiology, Statistical Genetics or a related quantitative discipline and a track record of research, including the analysis of high-dimensional data, published in high impact journals.
They will ideally also have experience analysing and interpreting associations with diet diaries and food frequency questionnaires.
We appreciate and value difference, seeking to attract, develop and retain a diverse mix of talented people that will contribute to the overall success of Bristol and help maintain our position as one of the world’s leading universities.