Postdoctoral Associate, Center for Biomedical Innovation

Location
Massachusetts, United States
Posted
09 Nov 2018
End of advertisement period
09 Jan 2019
Ref
16741
Contract Type
Permanent
Hours
Full Time

Working at MIT offers opportunities, an environment, a culture – and benefits – that just aren’t found together anywhere else. If you’re curious, motivated, want to be part of a unique community, and help shape the future – then take a look at this opportunity.

POSTDOCTORAL ASSOCIATECenter for Biomedical Innovation (CBI), to join CBI and affiliated faculty in performing research related to developing new processes for viral vector manufacturing. Therapeutics relying on viral vector-mediated gene modification, such as in vivo gene therapy or gene modified cell therapy, are expected to treat an ever-expanding set of diseases. There are currently forty-six gene therapies or cell-modified gene therapies in Phase III clinical trial in Q1 2018, with 557 therapies at earlier stages in the pipeline. The complexity of these therapies means that scaling up production to meet commercial demand while maintaining product quality is a challenge--a challenge that can potentially be met through the development of novel production approaches. Will design and execute experiments to establish the kinetics of transfection and production in bioreactor culture; develop and optimize upstream processes for cell growth, transfection, and vector harvest; and analyze and characterize cell culture and viral vector production processes using a variety of methods. Will report to professors Anthony Sinskey and Richard Braatz and Dr. Stacy Springs.  

Job Requirements

REQUIRED:  Ph.D. in biochemical or chemical engineering, biological sciences, or related field; experience with growth of mammalian or insect cells and/or virus production in small-scale vessels and bioreactors; bioreactor set-up, operation, and maintenance experience; experience analyzing cell culture medium components using HPLC and ELISA or similar methods; ability to prioritize multiple responsibilities, troubleshoot technical issues, and develop and execute detailed technical protocols; excellent organizational, written and oral communication, and documentation skills; ability to work independently and as part of a team; self-motivation; and attention to detail. Experience producing and characterizing plasmids and directing goal-oriented research preferred. Job #16741

This is a one-year position with the opportunity for extension based upon funding and satisfactory performance.  

11/2/18

MIT is an equal employment opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, sex, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, ancestry, or national or ethnic origin.