Doctoral Student in Electrophysiological Mechanisms Underlying In Vivo Maturation

Location
Stockholm, Sweden
Posted
02 Nov 2018
End of advertisement period
18 Nov 2018
Ref
2-6094/2018
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

Karolinska Institutet,

The Department of Molecular Medicine and Surgery (MMK) carries out both preclinical and clinical research within numerous fields. Linked to the department are approximately 450 researchers, postgraduate students, teachers and technical & administrative staff and we currently have about 150 PhD students. The department is conducting undergraduate courses for medical students, physiotherapist students, biomedicine students and biomedical laboratory students.

We are recruiting a student for doctoral education.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral.

Research group

The research group Signal Transduction is interested in complex signal-transduction in pancreatic islet cells under physiological and diabetic conditions. In recent years, the group has established the innovative and versatile approach “Non-invasive in vivo imaging of pancreatic islet cell biology” and successfully pioneered its application in the characterization of signal-transduction in islet cells and other cells. This technique will now be applied for in vivo promotion and characterization of human induced pluripotent stem cell-derived surrogate islets Read more:https://ki.se/en/mmk/signal-transduction-0

The doctoral education project and the duties of the student
Beta cell replacement therapy is one of the most important strategies for treating and curing diabetes, but is hindered by the scarce availability of pancreatic islets. Discoveries in stem cell research may revolutionize this therapy. Engineering of insulin-expressing cells from human induced pluripotent stem cells is a realistic approach. However, it is difficult to promote these cells to differentiate into highly specialized cells with the exquisite glucose sensitivity in vitro. The overall goal of this PhD project is to engineer and characterize highly-specialized, glucose-sensitive and insulin-secreting cells for diabetes therapy by an in vivo approach. The successful candidate will characterize pluripotent stem cell-derived surrogate islets in vitro, transplant these surrogate islets into the anterior chamber of the eye, promote and monitor in vivo differentiation of these surrogate islets.

Entry requirements for doctoral education at KI

To be eligible for doctoral education, the following requirements have to be met:

General entry requirements

A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  • has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  • has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  • has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

For more information regarding the general entry requirements, please see:
https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

Specific entry requirements

Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school. Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the English language requirement.

For information on how other applicants can certify their English proficiency (such as through IELTS or TOEFL, previous upper secondary or university level studies), please see:
https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

State here any other formal entry requirements, beside the above, that an applicant must have to be considered for this project.

Skills and personal qualities

Specify skills and personal qualities necessary or desirable/advantageous for this project. Make it clear for the applicants what is necessary and what is only desirable.

Assessment criteria

A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions

All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support.

Application process

The application must contain the following documents in Swedish or English:

  • A personal letter and a curriculum vitae
  • Academic degree diplomas, transcripts of records in original language and, if applicable, authorised translations
  • Copies of degree projects and any previous publications
  • Proof of English proficiency as stated in the specific requirement above
  • All documents certifying the entry requirements must be scans of originals (scans of copies or certified copies will not be accepted). The scanned documents must be in color and both the front and the back of the documents must be scanned. Please note that there are specific documentation requirements for a number countries, please read the instructions at: https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

The application and supporting documents are to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences.

The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employment PhD placement
Contract type Full time
Salary Månadslön
Reference number 2-6094/2018

Contact

Shao-Nian Yang, Associate Professor, shao-nian.yang@ki.se
Per-Olof Berggren, Professor, per-olof.berggren@ki.se

Union representative

Elisabeth Noren-Krog, OFR, 08- 517 70478
Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se

Published 01.Nov.2018
Last application date 18.Nov.2018 11:59 PM CET