Research Associate, Faculty of Biology, Medicine and Health

Manchester, United Kingdom
£32,236 - £35,211 Per Annum (according to relevant experience)
24 Oct 2018
End of advertisement period
22 Nov 2018
Contract Type
Fixed Term
Full Time

Location : Oxford Road, Manchester
Closing Date : 22/11/2018
Salary : £32,236 - £35,211 Per Annum (according to relevant experience) 
Employment Type : Fixed Term
Faculty / Organisational Unit : Biology, Medicine & Health
Division : Infection, Immunity & Respiratory Medicine
Hours Per week : Full Time
Contract Duration : 3 December 2018 until 2 December 2019

Project Title

Inhibiting Dual-Specificity Tyrosine Phosphatases (DUSPs) as a Method for Preventing Resistance to Herceptin in Her2-Positive Breast Cancer

Project Description

You will work on an ambitious programme of structure-based drug discovery to produce novel drugs to overcome resistance to Herceptin in HER2-positive breast cancer.

Molecular and systems-level research during the past two decades have led to development of anti-cancer drugs that act by inhibiting specific molecules that play key roles in tumorigenesis process or in tumour survival. A prime example of this is Herceptin (trastuzumab), an antibody that inhibits HER2 and is used to treat HER2-positive breast cancer. Despite its effectiveness, two thirds of patients who respond to Herceptin develop resistance and relapse within one year. Understanding the molecular basis for such resistance and devising methods to prevent or reverse it are therefore of critical importance. Our aim is to design new inhibitors of protein phosphatases, which function downstream of HER2 and are key regulators of signaling and survival in breast cancer.

We are looking for an enthusiastic individual, highly motivated with efficient skills in time managing and project leading. This post offers an excellent opportunity to join a dynamic research team focused on drug development in the School of Biological Sciences (Faculty of Biology, Medicine and Health)

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Name: Lydia Tabernero


Tel: 0161 2757794

General enquiries:


Tel: 0161 275 4499

Technical support:


Tel: 0161 850 2004

This vacancy will close for applications at midnight on the closing date

Further Particulars

BM&H-12935 Research Associate FPs;