Life Science Research Professional 2
Innovating at the forefront of diagnostic pathology, Stanford University is seeking a Life Science Research Professional 2 to perform more complex functions and activities involved in defined research projects, and independently conduct a portion of the research project(s) in the Nichols Lab.
About the Department of Pathology
Comprised of extraordinary faculty and staff, our mission is to improve the diagnosis, treatment and basic understanding of human disease. We accomplish this through our clinical services, research, and training the future leaders in pathology and related fields. A major focus of research in the Department is to innovate and assure Stanford’ pre-eminence in clinical diagnostics and prognostic testing molecular medicine. Everything we do is to provide the highest quality of pathology diagnostic services to the patients for whom we passionately care.
For more information about the department visit http://pathology.stanford.edu/
About the Position:
We are seeking a Life Science Research Professional to join the Nichols lab in the department of Pathology to study Parkinson’s disease. This LSRP will conduct research to uncover the molecular events that lead to neuronal cell death and pathology that cause Parkinson’s disease. In Parkinson’s disease, we believe that new drug targets for disease prevention or modification lie within the signal transduction pathways that intersect with proteins that are found mutated in Parkinson’s disease, especially ones that present clinically and pathologically similar to idiopathic disease. To undertake this research, the LSRP will have skills in cell biology and molecular biology methodologies such PCR, cloning, western blotting, and cell imaging. The LSRP must have basic computer skills and be a good team player and be involved with general lab organization as well as working to support departmental projects related to the lab.
- Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
- Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
- Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
- Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
- Participate in multidisciplinary teams across different faculties or schools.
- Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
- Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
- Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
- Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
*- Other duties may also be assigned
- Advanced degree in Genetics, Cell Biology, Biological Sciences or related field with minimum of three years of laboratory research experience desired.
- Experience planning and performing biochemical, cell biological and neuroscience procedures and analyzing data is required.
- Experience and knowledge of planning and performing the following items is highly desired:
- Standard molecular biology techniques for nucleic acid manipulation
- Biochemical procedures including protein expression and purification and enzyme assays;
- Immunological assays including: immunohistochemistry, immunofluorescence, flow cytometry, immunoprecipitation and bead-based assays.
- Basic aseptic technique with experience performing mammalian cell culture in a BS2 class hood
- Statistical analysis methods
- Experience and knowledge of planning and performing the following items is desired, but not required:
- Analysis of sequencing data, mass spectrometry data and experience with large data sets
- Experience working with blood from mammalian sources
- Preparation of tissues and slides for histologic and biochemical analysis.
- Culture and differentiation of iPSCs
The candidate should be able to work independently, be highly motivated, well organized, adaptable and work well within a highly interdisciplinary and international team.
EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and two years of relevant work experience; or Master’s degree in a related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- Comprehensive understanding of scientific principles.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
- Strong analytical skills and excellent judgment.
- Ability to maintain detailed records of experiments and outcomes.
- Ability to work under deadlines with general guidance is essential.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
- Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
- Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
- Must have correctable vision to perform duties of the job.
- Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
- Ability to lift heavy objects weighing up to 50 pounds.
- Ability to work in a dusty, dirty, and odorous environment.
- Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
- May require working in close proximity to blood borne pathogens.
- May require work in an environment where animals are used for teaching and research.
- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research requirements and business needs.