Research Associate in Synthetic Biology/Metabolite Engineering of Actinomycetes

Manchester, United Kingdom
£32,236 to £39,609 per annum, depending on experience
05 Oct 2018
End of advertisement period
05 Nov 2018
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Full Time

Location : Oxford Road, Manchester
Closing Date : 05/11/2018
Salary : £32,236 to £39,609 per annum, depending on experience
Employment Type : Fixed Term
Faculty / Organisational Unit : Science & Engineering 
Division : 
Hours Per week : Full time
Contract Duration : Available from 1 January 2019 until 31 December 2019. There will be a possibility to extend the position for a further 12 months.

Applications are invited for a Research Associate to work on the H2020 funded “TOPCAPI: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients” project based within the Manchester Institute of Biotechnology. This project involves a total of 8 academic and industry partners from 4 different EU countries. The aim of the TOPCAPI project is to exploit the natural fabrication power of actinomycetes as microbial cell factories to produce high-value pharmaceutical ingredients.

You will have skills in genetics of Streptomyces coelicolor and synthetic and/or molecular biology allied to strong interests in genome editing and metabolic engineering. The appointee will join a team of researchers in the TOPCAPI consortium, working with another experimental PDRA and a technician based in the Manchester Institute of Biotechnology.

The project will be working to exploit actinomycetes to produce high-value pharmaceutical ingredients, in particular, the starter compound for the semi-synthesis of a new topical anti-acne drug currently in Phase II clinical trials, and intermediates for the semi-synthetic production of medically important type II polyketide tetracyclines to be used against methicillin-resistant Staphylococcus aureus infections (MRSA). A strong commitment to team-based work is required with strong background in synthetic biology, molecular biology and actinomycetes genetics. This project will be supervised by Professor Eriko Takano.

You will hold a PhD (or equivalent) in (Biology/Biochemistry) (or a related subject area), and have technical skills in synthetic and/or molecular biology, and metabolic engineering allied to strong interests in genome editing.

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. An appointment will always be made on merit.

For further information, please visit:                                                                            

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Professor Eriko Takano


Tel: +44 (0)161 306 4419

Technical support:


Tel: 0161 850 2004

General enquiries:


Tel: 0161 275 4499

This vacancy will close for applications at midnight on the closing date

Further Particulars and Job Description

S&E-12839 Research Associate in Synthetic Biology/Metabolite Engineering of Actinomycetes FP's;  

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