This position is responsible for managing day to day operations. Under the direction of the PI but with latitude to exercise independent judgment, this position will have the role of planning research projects, designing experiments, training staff, ensuring all safety and research compliances are met, managing sponsored research awards, and managing a unique animal colony. The lab focuses on developing humanized mouse models recapitulating early B cell tolerance checkpoints and their defects in autoimmune settings such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes and systemic sclerosis. These allow now in-depth investigation of tolerance mechanisms and the development of novel approaches to restore defective central and peripheral B cell tolerance checkpoints to thwart autoimmunity. This humanized mouse model is also suitable for understanding autoimmune mechanisms induced by anti-CTLA-4 and anti-PD-1 checkpoint inhibitors in cancer patients. The successful candidate will investigate these humanized mouse models in combination with patient samples to answer fundamental questions regarding tolerance mechanisms and how to control them. Proficiency in cell culture, molecular biology and flow cytometry is required and excellent communication and writing skills are preferred.
- Recommends the design and implementation of procedures and protocols under the direction of a higher-level authority.
- Investigates, analyzes, and reaches preliminary scientific conclusions related to research planning
- Ensures data results are compiled, analyzed, and presented properly.
- Analyzes, develops and interprets scientific results. Maintains clear documentation of results. Prepares scientific reports and papers for research proposals and published reports.
- Performs independent research and laboratory techniques and participates in experimental research planning.
- Interacts with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory.
- Interacts with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments.
- May perform other duties as assigned.
Required Education and Experience
Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.
Required Skill/Ability 1:
Demonstrated ability with cell culture, molecular biology and flow cytometry.
Required Skill/Ability 2:
Ability to manage budgets, supply inventory, purchase equipment and provide maintenance.
Preferred Education, Experience and Skills:
Ability to harvest mouse organs, extract cells and purify B and T cells using magnetic beads.
Weekend Hours Required?
Evening Hours Required?
Background Check Requirements
All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. Please visit www.yale.edu/hronline/careers/screening/faqs.html for additional information on the background check requirements and process.
The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the particular position. Employees will be assigned specific job-related duties through their hiring departments.
Affirmative Action Statement:
Yale University considers applicants for employment without regard to, and does not discriminate on the basis of, an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression. Title IX of the Education Amendments of 1972 protects people from sex discrimination in educational programs and activities at institutions that receive federal financial assistance. Questions regarding Title IX may be referred to the University’s Title IX Coordinator, at TitleIX@yale.edu, or to the U.S. Department of Education, Office for Civil Rights, 8th Floor, Five Post Office Square, Boston MA 02109-3921. Telephone: 617.289.0111, Fax: 617.289.0150, TDD: 800.877.8339, or Email: email@example.com.