Senior Research Investigator

Pennsylvania United States
11 Oct 2018
End of advertisement period
11 Dec 2018
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Full Time

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education.

This position requires a senior scientist, with significant experience in cell and molecular biology and granting writing experience, to conduct research in cutaneous biology, specifically to investigate epithelial stem cells, hair follicle biology and wound healing. The position requires developing novel methods and models for skin and hair regeneration, carrying out research involving mouse studies and human iPS cells. It also requires bioinformatics and bioengineering skills. The incumbent will be in charge of designing, coordinating and executing research studies independently, proposing hypothesis and establish novel techniques in consultation with the PI, presenting study results in scientific meetings, preparing manuscripts and presentations, assisting grant applications, and training students.

Ph.D., or equivalent doctoral degree in biological sciences and at least 5 years to 7 years of experience required. The preferred candidate will have at least 5 years experience working in the field of hair follicle biology, wound healing and skin regeneration. The candidate should be familiar with primary skin cell isolation and FACS analysis; is an expert in iPS cell generation, culture and differentiation towards skin cells, and familiar with in vivo and in vitro hair reconstitution assays. The preferred candidate should have extensive knowledge on molecular pathways that are critical in hair biology, including Wnt, Hedgehog, and IGF pathways. The candidate is expected to be familiar with characterization of epigenetic modifications during stem cell differentiation. The preferred candidate should be an expert in FACS analysis, RNA and protein markers analysis, retro-viral transfection, RNA-seq and bioinformatics skills. The highly preferred candidate will have a proven record of publications and experience with assisting in the development of grant applications, management skills in leading a small group, and excellent communication skills.

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.