Life Science Research Professional
The Department of Radiology is seeking a Life Science Research Professional 1 (LSRP) to join the Stanford Cardiovascular Institute Biobank (SCVI Biobank). We seek to recruit an ambitious and talented LSRP wishing to apply their molecular biology skills to identify therapeutic targets for cardiovascular diseases. The successful candidate will use cutting-edge technology, including induced human pluripotent stem cells (iPSCs), CRISPR/Cas9 genome editing and genomics. Under the direction of senior scientists, the Life Science Research Professional will perform basic functions and activities involved in defined research projects, and independently conduct and analyze experiments.
The LSRP will also perform cell culture to reprogram patient-specific fibroblasts or blood sample into induced pluripotent stem cells for therapeutic purposes. Upon successful scale-up, the LSRP will oversee the high throughput derivation of cardiomyocytes from patient-specific iPSCs. The candidate must be able to track and manage a very large number of samples. This position is fast paced and physically demanding. The responsibilities may include weekend and holiday reporting for cell culture responsibilities, as needed.
The candidate will be a member of a multi-disciplinary team consisting of molecular biologists, geneticists, and computational scientists. The project builds on recent initiatives at the SCVI Biobank to generate large numbers of human iPSCs. The aim of the project is to identify genes and pathways relevant for cardiovascular disease. The candidate will be responsible for optimizing a cellular model based on iPSC-derived cardiomyocytes and characterizing these cells on the cellular and molecular level. In addition, the successful candidate will validate selected candidate genes in these cells using CRISPR/Cas9 genome-editing methods.
- Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.
- Independently conduct experiments; maintain detailed records of experiments and outcomes.
- Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
- Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
- Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
- Assist with orientation and training of new staff or students on lab procedures or techniques.
*- Other duties may also be assigned.
- A Bachelor of Science in molecular biology or related discipline or equivalent experience.
- Experience and excellent practical skills in human cell culture techniques.
- Experience in the application of a range of molecular biology methods.
- Excellent organization and record-keeping skills.
- Ability to work both independently and as part of a team.
- Ability to communicate effectively with team members and collaborators.
- Experience and understanding of biological safety regulations and procedures.
EDUCATION & EXPERIENCE (REQUIRED):
- Bachelor's degree in related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
- Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
- Ability to maintain detailed records of experiments and outcomes.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
- Ability to work under deadlines with general guidance.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
- Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
- Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
- Must have correctible vision to perform duties of the job.
- Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
- Ability to lift heavy objects weighing up to 50 pounds.
- Ability to work in a dusty, dirty, and odorous environment.
- Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
- May require working in close proximity to blood borne pathogens.
- May require work in an environment where animals are used for teaching and research.
- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research requirements and business needs.
- Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
- Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
- Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu.