Location : Oxford Road, Manchester
Closing Date : 09/10/2018
Salary : Grade 6/7 £32,236 to £50,132 per annum according to experience
Employment Type : Fixed Term
Faculty / Organisational Unit : Science & Engineering
Division : Computational and Theoretical Chemistry
Hours Per week : Full Time
Contract Duration : 28 months
We are seeking a talented Computational Chemist/Biochemist to develop new approaches for accelerating the directed evolution of enzymes.
You will work on constructing accurate in silico models of mutant enzymes using comparative modelling and graphics processor accelerated fully solvated dynamics simulations. You will integrate these simulations into the predict-design-test-build-learn cycle of directed evolution to allow the most important beneficial mutations to be identified at each iteration. You will have a relevant PhD in computational chemistry/biochemistry and substantial experience of working with proteins, performing molecular dynamics simulations, analysing and visualising the results.
You will work closely with an experimentalist who will be performing directed evolution using new and smarter synthetic-biology-based mutagenesis. The ability to work both independently and communicate with experimentalists will be essential. In the first instance you will show proof-of-principle on monoamine oxidase, for which we already have extensive experience, and will draw on the excellent infrastructure found within the Manchester Institute of Biotechnology.
The School of Chemistry is strongly committed to promoting equality and diversity, including the Athena SWAN Charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff to achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit http://www.chemistry.manchester.ac.uk/about-us/athena-swan/
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies
Enquiries about the vacancy, shortlisting and interviews:
Name: Andrew Almond
Tel: 0161 275 4499
Tel: 0161 850 2004
This vacancy will close for applications at midnight on the closing date