NATIONAL UNIVERSITY OF SINGAPORE

Research Assistant, Pharmacy

7 days left

Location
Singapore
Posted
Apr 20, 2021
End of advertisement period
May 20, 2021
Ref
3782444
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Permanent
Hours
Full Time

Job Description

The successful candidate will work with A/Prof Victor Yu to study the role of MOAP-1 in aging and regulation of metabolism and obesity.

Responsibilities include:

  • Providing research support to the project.
  • Preparing procedures, protocols and reports.
  • Providing support with mice husbandry and animal experimentation/procedure.
  • Conducting experiments using modern molecular biology techniques such as PCR, quantitative RT-PC, western blot, CRISPR and immunofluorescence/immunohistochemistry.
  • Performing administrative duties such as housekeeping and purchasing.

To facilitate a better understanding of the work being pursued in the laboratory, prospective applicants are urged to refer to the following recent papers published by the laboratory: 

  1. K.O. Tan et al., MAP-1 is a mitochondrial effector of Bax, (Track II), Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005. 
  2. N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, (Track II),  Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007. 
  3. N.Y. Fu et al., Baxβ: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism, Molecular Cell,  33: 15-29, 2009. 
  4. S.K. Sukumaran et al., A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010 
  5. C.T. Tan et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria, Cell Reports, 16:174-85, 2016
  6. C.T. Tan et al., MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling, EMBO reports, 22(1), 2021.
  7. H.C. Chang et al., The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore, Autophagy (in press).

Qualifications

  • Qualifications / Discipline:

Bachelor’s Degree in Science

  • Skills:
  1. Cell culture, DNA and protein work.
  2. Effective oral and written communication skills.
  3. Proficient with Microsoft Word and Excel.
  4. Capable of multi-tasking and effective time management.
  5. Motivated and able to function effectively in team setting.
  • Experience:  

Prior experience in working in a research lab setting in life sciences will be given priority in the selection process, especially those with prior experience with cell culture, DNA, protein or mouse work.

More Information

Location: Kent Ridge Campus
Organization: Science
Department : Pharmacy

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