This position is for a talented and ambitious postdoctoral scientist to work on a BHF-funded programme on redox-regulated adaptive pathways in heart failure, with specific focus on metabolism, growth and stress responses. Previous experience in the in vivo characterisation of cardiac function in experimental models of cardiac overload or MI (e.g. with high resolution echocardiography, MRI) and in isolated heart perfusions is highly desirable. The project will also include ex vivo analyses (e.g. histology, immunostaining), cell, molecular biology and metabolomic assays. Training will be provided in those techniques that are unfamiliar to the appointee.
The postholder will be part of a multi-disciplinary team working on several related aspects of cardiovascular pathophysiology, with access to state-of-the-art laboratory facilities within the King’s BHF Centre of Research Excellence.
- Develop and undertake research of high quality consistent with making a full active research contribution in line Department/School research strategy.
- Manage specific pieces of activity to an agreed timeline and within a specific budget including literature reviews, data collection and analysis, report writing.
- Attend and, as appropriate, present research findings and papers at internal academic meetings and external professional conferences, and to contribute to the internal and external visibility of the department.
- Work as a conscientious and committed member of the team in order to achieve the aims of the projects lab group.
- Facilitate collaboration and networking which engages and supports the activities of the project
- Participate in educational activities as appropriate to the stage of your career.
- To be committed to your own personal career development.
- Liaise with the administrative team for the support of the project.
- Contribute to publications arising from this project.
- Undertake any other reasonable duties that may be relevant to the role outline.
Communication & Networking:
- Deal with routine communication using a range of media
- Communicate complex information orally and in writing
- Communicate material of a specialist or highly technical nature
- Liaise with colleagues and students
- Build internal contacts and participate in internal networks for the exchange of information and to form relationships for future collaboration
- Join external networks to share information and identify potential sources of funds
Decision Making, Planning and Problem Solving:
- Use new research techniques and methods
- Identify areas for research, develop new research methods and extend the research portfolio
- Contribute to collaborative decision making with colleagues in area of research
- Respond to requests for information in accordance with College policies
- Provide advice with respect to own areas of expertise
- Set the standards of service and ensure overall quality is maintained
Analysis & Research:
- Develop research objectives and proposals for own or joint research, with the assistance of a mentor
- Conduct individual and collaborative research projects
- Write up research work for publication
- Maintain knowledge, expertise and awareness of relevant research literature by self-directed enquiry and continuing education
- Translate knowledge of advances in the area of expertise into research activity
- Analyse and interpret research data and draw conclusions on the outcomes
Team Work, Teaching & Learning Support:
- Work with colleagues on joint projects as required
- Collaborate with academic colleagues on areas of shared research interest
- Attend and contribute to relevant meetings
- Contribution to the supervision or training of more junior staff and students as necessary
- Contribution to laboratory maintenance and administration
Show consideration to others
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
- Background in cardiovascular biology
- Good written presentation and communication skills (both written and verbal)
- Good IT skills
- Cardiovascular research experience
- Successful completion of research projects (published papers in high Impact Factor journals)
- Home Office Personal Licence or equivalent
- Cell and molecular biological techniques
- Self-motivated and able to work either independently or as part of a team
- Ability to carry out known/learnt techniques unsupervised
- Flexible/able to respond to change in current professional context
- Ability to plan and prioritise own workload and to keep clear and well-organised laboratory notes and records
- Commitment to continuing personal and professional development
- Background in redox signalling
- Langendorff heart perfusion
- In vivo cardiovascular physiology (e.g. echo, MRI)
- Histology, immunocytochemistry
- Gene-modified models including breeding strategy and genotyping