Director, Immunology Discovery Research

Pennsylvania, United States
Jul 20, 2020
End of advertisement period
Sep 20, 2020
Contract Type
Full Time

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Job Profile Title
Director D

Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Continuation of all GTP positions is contingent upon grant funding.

Job Description

GTP is currently looking for a Director, Immunology Discovery research to help further explore immunological questions as it relates to adeno-associated viral vectors (AAV) and other gene therapy platform technologies.

As the Director of Immunology Discovery Research, you will oversee immunology research within the discovery research team that will have a translational application to GTP programs. You will also work in tandem with our Clinical Development team during any adverse events that occur during our trials and perform research studies to the elucidate immune response to AAV Gene Therapy and other clinical programs and contribute to the development of remediation strategies. You will work in large interdisciplinary teams where you will perform design, optimization, and implementation of sophisticated experiments within specified timelines. You will contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.

In addition, you will build a high-performing research team where you will mentor and provide direct oversight to Ph. D. researchers and other scientific staff. You will establish the goals of research projects and work with your team to meet program timelines. You will work closely with GTP Leadership to ensure that the research program stays within budget. In consultation with the Director of Gene Therapy, you will assess immunology discovery programs that are brought into GTP for scientific research.

The successful candidate will have extensive experience with immunology, molecular virology, and protein structures & functions. Also, you will have expertise in T-cell biology, innate immunity, and the complement activation/inflammation.


  • Ph. D. in the field of Immunology, Molecular Virology, or other related fields and 5+ years of direct laboratory research experience after the completion of Ph. D. is required.
  • Research experience in immunology as demonstrated by scientific publications is required; research expertise in T-cell biology, innate immunity, and complement system is strongly preferred. 
  • Must be a self-starter but also a strong desire to contribute and work collaboratively to achieve goals.
  • Success in roles requiring execution of multiple tasks while responding to multiple priorities.
  • Highly functioning, detail-oriented, and analytical candidate who can think strategically Excellent oral/written communication skills required.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$88,861.00 - $168,837.00

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.