Research Fellow, Centre for Cancer Research and Cell Biology
Application closing date 30/03/2020
Salary £33,797 to £40,322 per annum.
Job category/type Research
Available immediately to work as part of the Health Data Research UK (HDRUK) Substantive Site at Queen's University Belfast, within the colorectal cancer Molecular Pathology Research Group (www.dunne-lab.com). The Research Fellow will join our internationally renowned research team based in the Patrick G Johnston Centre for Cancer Research. HDRUK is the national institute for health data science in the United Kingdom. Queen's University Belfast together with its partner Swansea University constitutes one of the six substantive sites of HDRUK - HDR Wales-Northern Ireland.
Recent advances in molecular profiling analysis by our group and others have identified molecular subtypes in Colorectal Cancer, based on previously defined histological subtypes (Consensus Molecular Subtypes; CMS) and neoplastic epithelial biology (ColoRectal Intrinsic Subtypes; CRIS). This approach to molecular subtyping involves a combination of molecular biology, computational analysis and pathological assessment, enabling an integrated evaluation of multiple layers of molecular information. Our lab has unparalleled access to molecular data from the tumour datasets used to develop both CMS and CRIS, as part of the S:CORT programme (www.scort.org.uk) and emerging molecular profiles from state-of-the-art pre-clinical models of disease that, for the first time, recapitulate human tumour subtype in 2D/3D cell lines, organoids and mouse models (PDX and GEMM), as part of our leading role in the ACRCelerate programme (http://www.beatson.gla.ac.uk/ACRCelerate/teams.html).
The successful candidate will become an integral member of a dynamic, collaborative and well equipped research group that puts a strong focus on interdisciplinary data-driven research. Our group provides a stimulating research environment where collaboration and development of new ideas is strongly encouraged, alongside support for career development for emerging talents. The overarching goals of this research group is to develop a greater understanding of disease to improve survival rates for patients with CRC, through precise dissection of the signalling pathways underpinning initiation, invasion and metastasis in CRC.
Applicants must have experience with state-of-the-art molecular stratification using transcriptomic and mutational data, enabling them to utilise the unique data from our human tissue samples and mouse tumour models to develop new, and refine existing, molecular subtypes in CRC through a combination of translational bioinformatics and molecular biology. Overall, this project aims to unveil the interplay between the epithelial tumour and surrounding immune/stromal cells to ultimately improving our understanding of CRC. The successful candidate will become a HDRUK Fellow and will be part of a UK-wide fellow community and participate in HDRUK Summer Schools and other training activities with HDRUK partner organisations including the Medical Research Council (MRC).
The successful candidate must have:
- Hold (or about to obtain) a PhD in molecular cancer biology, bioinformatics or a related discipline.
- At least three years relevant research experience (including PhD experience).
- Experience with transcriptional data analysis and/or bioinformatics.
- Experience with colorectal cancer biological signalling.
- Publication of peer-reviewed papers that include a large component of bioinformatics analysis.
Established in 2007, The Patrick G Johnston Centre for Cancer Research is a 5,000m2 purpose-built interdisciplinary centre, comprised of scientific teams from Biomedical Science, Clinical Medicine, Chemistry, Mathematics, Engineering and Radiobiology. The centre works collaboratively with partners around the world in order to translate research into innovative cancer treatments that enhance and extend life.
The Patrick G Johnston Centre for Cancer Research is the beating heart of a comprehensive cancer research programme in Belfast, focused on accelerating the delivery of scientific discovery to clinical application. The Patrick G Johnston Centre for Cancer Research is the research hub of the Belfast ECMC and the Belfast Experimental Cancer Medicine Centre (ECMC), operating in partnership with the Belfast Health and Social Care Trust. Our integrated clinical and scientific programmes address clinically unmet needs. Our principal objective is to promote evidence-based, innovative clinical trials in order to underpin improved patient outcomes in high incidence solid tumours of Gastro-Intestinal, Prostatic, Breast and Ovarian origin, and in specific Blood Cancers. Our unifying research theme is to develop translational outputs, in the form of biomarkers and/or novel therapeutic strategies that enable our Centre to be at the forefront of personalised cancer medicine in these prevalent diseases.
Queen's University Belfast is a driver of innovation based on our talented, multinational workforce. Throughout the University, our academics are collaborating across disciplines to develop new discoveries and insights, working with outside agencies and institutions on projects of international significance. We are connected and networked with strategic partnerships across the world, helping us to expand our impact on wider society locally, nationally and globally. The University is committed to attracting, retaining and developing the best global talent within an environment that enables them to realise their full potential.
We are a leader in gender equality and diversity, and are one of the UK's most successful universities in the Athena SWAN initiative which promotes gender equality and career progression. The School of Medicine, Dentistry and Biomedical Sciences currently hold a prestigious Athena SWAN Silver award. We are ranked 1st in the UK for knowledge transfer partnerships, (Innovate UK) 9th in the UK for University facilities (Times Higher Education Student Experience Survey 2018) and 14th in the UK for research quality (Times and Sunday Times Good University Guide 2019).
Based in Belfast, a modern capital city, our beautiful campus is surrounded by abundant acres of parkland and is renowned as one of the safest and affordable cities in the UK. The choice of local Schools from pre-nursery upwards are some of the best available, and lovers of the outdoors can enjoy any number of activities from rowing and kayaking to top class golf among many others. We are immensely proud of what our city and our University will offer you.
Informal enquiries may be directed to Professor Dan Longley via email to firstname.lastname@example.org