Are you an ambitious researcher looking for your next challenge?Do you want your research to have a direct impact on the identification of disease mechanisms and the development of new treatments? Do you have a background in molecular and cellular biology?Do you want to further your career in one of the UK’s leading research intensive Universities?

You will pursue a project aimed at identifying the molecular mechanisms that lead to the pathogenesis of the aggressive B-cell malignancy mantle cell lymphoma. This project builds from our previous work that has identified the mechanisms of transcription factors that are often erroneously activated in B-cell tumours due to genetic mutations in the tumour-precursor cells. 

The project will aim to understand the oncogenic function of these transcription factors in the pathogenesis of mantle cell lymphoma, and to identify new molecular targets for the treatment of this tumour. This is the most critical step towards the realization of precision medicine in the treatment of this currently incurable malignancy. You will make use of a large spectrum of techniques, including in vitro assay systems, RNA-interference and CRISPR/Cas9-mediated manipulation of cell lines, flow cytometry and genomics approaches.  

You should have, or be about to obtain, a PhD in a biological science or a closely allied discipline with a strong background in molecular and cellular biology. You will use your initiative to creatively identify areas for research and extend the research portfolio of the project and group. As you will work closely, interactively and collaboratively with our project team, you will need excellent communication skills.

To explore the post further or for any queries you may have, please contact: 

Professor Ulf Klein, Professor of Immunology and Haemato-oncology
Email: U.P.Klein@gmail.com

Further Information

The University of Leeds is committed to providing equal opportunities for all and offers a range of family friendly policies. The University is a charter member of Athena SWAN and holds the Bronze award. The School of Medicine holds the Gold Award.  We are committed to being an inclusive medical school that values all staff, and we are happy to consider job share applications and requests for flexible working arrangements from our employees.

Location:  Leeds - St James University Hospital
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  Leeds Institute of Medical Research (LIMR)
Section:  Haematology & Immunology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Working Time:  Full time
Post Type:  Full Time
Contract Type:  Fixed Term (3 years - research funded)    
Closing Date:  Friday 06 March 2020    
Downloads:  Candidate Brief