Research Fellow, Biological Sciences

Tuesday, 7 December 2021
End of advertisement period
Thursday, 6 January 2022
Contract Type
Full Time

Job Description

The Tan lab is looking for a post-doctoral candidate who will work with Assistant Professor Tan Yong Zi on biochemistry and structural biology under a project entitled Understanding the Structure and Function of Mammalian Membrane Proteins Involved in Human Diseases.

While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. The Tan lab ( strives to fill in this gap by targeting membrane proteins involved in human diseases such as cancer and diabetes. Our forte is using state-of-the-art single-particle cryogenic electron microscopy (cryo-EM) to obtain high-resolution atomic structures of these membrane proteins. We also actively work on methods development in cryo-EM that will help us answer our biological questions.

The Tan lab is generously funded by the NUS Presidential Young Professorship under the Department of Biological Sciences, NUS. We are a core member of the Centre for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter.

Main Responsibilities

  • Lead structural projects from protein expression, protein purification, activity assay, cryo-EM imaging, data processing and model building

Application Requirements

  • Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work
  • PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field
  • Experience with bacterial, insect and mammalian cell culture work is not essential but favoured
  • Experience in protein purification experience is required
  • Programming (such as Python) skills not essential but favoured
  • Structural biology experience  not essential but favoured

Interested candidates please contact Dr. Tan Yong Zi at Please provide a CV and names and contact of three referees.


PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field

More Information

Location: [[Kent Ridge]]
Organization: [[National University of Singapore]]
Department : [[Biological Sciences]]
Employee Referral Eligible: [[No]]
Job requisition ID : 8313

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