Research Associate

London (Greater) (GB)
£38,826 to £39,882 per annum including London Weighting Allowance
Thursday, 2 December 2021
End of advertisement period
Friday, 7 January 2022
Contract Type
Fixed Term
Full Time

Job description

Your role will be to identify neuropathological signatures of RNA binding proteins in post-mortem tissue from patients that carry Mendelian mutations in genes causative for Amyotrophic Lateral Sclerosis.

The research activities of the post will include sectioning of post-mortem fixed tissue, performing immunohistochemistry (DAB and fluorescent co-staining), in situ hybridizations, light and confocal microscopy and preparation of frozen tissue for western blotting, immunoprecipitation, DNA and RNA extraction and additional related techniques where necessary.


The role will be split between the London Neurodegenerative Diseases Brain Bank and the Maurice Wohl Clinical Neuroscience Institute (both sites on the Denmark Hill campus). This postdoctoral position offers an opportunity to bridge neuropathology and molecular investigation in ALS and the role will be actively working with an extended team of ALS researchers in both centres. The appointee will be provided with a supportive environment in which to develop research skills and to present research findings to peers and at conferences.


This post will be offered on an a fixed-term contract for 30 months

Full time post – 100% full-time equivalent


Key responsibilities

  • Perform laboratory research on post-mortem tissue from Amyotrophic Lateral Sclerosis (ALS) patients 
  • Prepare tissue accordingly and extract DNA, RNA and protein for downstream experiments
  • Maintenance and record keeping of tissue and experiments using Microsoft Office and online, in-house King’s databases and managing administration associated with the research project 
  • Regular meetings and communication with line managers and researchers on the project. 
  • Present research findings at regular workshops and seminars within the Wohl and Kings and at conferences 
  • Maintain confidentiality and sensitivity of patient tissue utilized for research experiments. 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

1.       PhD required

2.       Experience with handling and sectioning post-mortem tissue 

3.       Extensive wet lab experience encompassing western blotting, immunoprecipitation, light and confocal microscopy and imaging using varying platforms, quantification of IHC data, DNA, RNA and protein extraction and a working knowledge of                    statistics packages. 

4.       Be reliable, diligent, communicative and demonstrate professional interpersonal skills 

5.       Rigorous attention to detail 

6.       Ability to work independently and in a team 

7.       Knowledge of neurodegenerative diseases and human brain anatomy 


Desirable criteria 

1.       Knowledge of ALS genetics 

2.       Publications/s in the field of neurodegeneration 


Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.


This post is subject to a Occupational Health Clearance.

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