This fully-funded postdoctoral fellowship is offered in the Elosegui-Artola lab based at the Francis Crick Institute. ( https://www.crick.ac.uk/research/labs/alberto-elosegui-artola). The Cell and Tissue Mechanobiology lab started at the Francis Crick Institute in June 2021. We have strong core funding and we have been awarded an ERC Starting Grant. The Francis Crick Institute is a world-class biomedical research institute dedicated to understanding the fundamental biology underlying health and disease. The Institute has state-of-the-art facilities and technology platforms like advanced-light microscopy, bioinformatics, high-throughput screening, microfabrication or electron microscopy.
We are looking for researchers interested in a multidisciplinary approach to determine the interplay between mechanical and chemical cues in living tissues. We utilize a variety of cellular systems like 3D organotypic systems, organoids and primary cells, combined with 3D matrix engineering and microfluidics coupled to advanced microscopy to gain a fundamental understanding of the role of mechanics in tissue behaviour. Some of the specific aims are: to study the interaction between tumours and the stroma, to analyse the role of the extracellular matrix in organoid morphogenesis in health and disease; to unravel the mechanical and molecular mechanisms that cells utilize to sense the 3D extracellular matrix; to guide tissue response through mechanical cues.
The suitable applicant will use a wide range of cutting-edge techniques including biophysical tools, advanced microscopy, image analysis, RNA sequencing, molecular biology, bioinformatics, 3D biomaterials and microfabrication. We are looking for candidates with a PhD in biology or similar (or be in the final stages of completion). Previous experience in biophysical or biomechanical setups at the cell and/or tissue levels will be greatly appreciated (but not strictly required). Candidates with a strong background in advanced confocal imaging, imaging analysis, 3D organotypic models, or organoids are also encouraged to apply.
This post will be offered on an a fixed-term contract for 4 years
This is a full time post