Research Assistant in Infectious Diseases
SARS-CoV-2 continues to infect millions of people worldwide, with devastating consequences for global health. While vaccination and immunity arising from natural infection are effective in limiting new infections, there is an urgent need to understand the threats and risks associated with emerging viral variants. In response, ten UK research groups have established “G2P-UK; A National Virology Consortium to address phenotypic consequences of SARS-CoV-2 genomic variation”. Led by investigators from Imperial College London, King’s College London, the Glasgow Centre for Virus Research and the Pirbright Virology Institute, G2P employs multi-disciplinary approaches to define the characteristics of emerging viral variants, aiming to understand the genetic, immune, molecular and cellular basis for altered phenotypes. These results will inform public health policy and clinical practice, including treatment strategies, diagnostics and infection control, and vaccination.
We seek to recruit an enthusiastic and highly motivated research assistant to join the G2P team at King’s College London to work in the labs of Michael Malim, Katie Doores and Stuart Neil in the Dept of Infectious Diseases. We are looking for an MRes/MSc or BSc level researcher with hands on laboratory experience to join an interactive team of post-doctoral fellows, research assistants and post-graduate students studying innate and adaptive immune responses to SARS-CoV-2. Initial projects will include serological and virus neutralisation assays with patient and vaccine samples, the isolation and characterisation of human monoclonal antibodies, and the characterisation of viral infections in cell culture.
The appointee will be expected to display experimental and technical leadership, contributing to research publications, presentations at international meetings/ conferences, and applications for extra-mural research funding.
This post will be offered on an a fixed-term contract until 31 July 2022
This is a full-time post – 100 % full time equivalent
The use of laboratory techniques and strategies to meet the objectives outlined above, including the willingness to work in containment level 3 (CL3) facilities.
• To provide technical support for SARS-CoV-2 related research.
• To conduct serological assays to investigate humoral immune responses to SARS-CoV-2.
• Undertake cell-based virus neutralisation assays.
• Express and purify viral antigens and virus-specific antibodies.
• To collaborate with members of the Department working in related projects
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
• BSc or equivalent in a biomedical, biological, or biochemical field.
• Experience with laboratory/experimental work.
• Ability to maintain accurate laboratory records.
• Ability to interpret experimental results.
• Ability to follow both written and oral instructions.
• Ability to communicate and work as part of a team.
• Willingness to learn new techniques.
• Good organisational skills.
• Self-motivated, flexible and co-operative.
• Masters level degree ideally in a biological or biochemical field.
• Experience of working with cultured mammalian cells.
• Experience with serological assays, protein expression and purification.
• Experience with molecular biology techniques including PCR and DNA sub-cloning
• Experience with tissue culture and transfection of mammalian cells.
This post is subject to Disclosure and Barring Service and Occupational Health clearance.
SARS-CoV-2, immune responses, antibodies, infection