Clinical Trials Research Fellow
Clinical Trials Research Fellow
Job ID: 028485
Salary: £40,856, including London Weighting Allowance
Posted: 26-Jul-2021 Closing date: 09-Aug-2021
Denmark Hill Campus Research
The primary role of the clinically trained appointee will be to manage and undertake assessments and dosing in gene therapy trials involving people with amyotrophic lateral sclerosis (ALS). The clinical trial will involve identifying patients that fit the trial inclusion criteria, explaining the nature of the trial to them in detail and, if they are willing to take part, obtaining their full informed consent. Once consented they will be formally enrolled in the trial which will involve the intrathecal administration of antisense oligonucleotides (ASO) to knock down specific genes that are either themselves mutated or contribute to disease pathogenesis. In addition, the appointee may have the opportunity to be involved in a research project that is related to biomarker development and therapeutic response with a view to publishing papers, presenting at international conferences and building pilot data for a potential future PhD project. The appointee will be based in the Maurice Wohl Clinical Neuroscience Institute on the Denmark Hill Campus and the patient-centred work will be carried out in the Clinical Trials Facility at King’s College Hospital.
The successful candidate will be part of a team working on developing and testing gene therapies aimed at treating amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD). Currently scheduled trials will involve the intrathecal administration of antisense oligonucleotides (ASO) to the genes C9orf72, SOD1 and FUS. These patients will require CSF and blood samples to be taken for safety and biomarker studies. In addition, we anticipate that there will be an option to undertake a parallel research project that relates to biomarker development and/or drug therapies in ALS. Preference will be given to researchers keen to submit their work for publication in journal articles and presentation at international conferences.
We are looking for a highly motivated, hard-working clinical trainee at Senior House Office or Specialist Registrar level, who can work independently but also interact creatively within the team. No experience of clinical trial work is required other than a passionate curiosity about science and a commitment to deliver new therapies for patients with neurodegenerative disorders.
This post will be offered on an a fixed-term contract for 12 months
This is a full-time post
- Identify, recruit and consent suitable patients for gene therapy trials.
- Examine these patients periodically as part of the trial protocol and accurately record the data.
- Perform lumbar punctures and take blood for biomarker studies and to deliver the therapy.
- Carry out the collection, analysis and interpretation of the data.
- Conduct literature reviews and contribute to publications arising from this project.
- Attend and present research findings and papers at internal and external academic meetings and external professional conferences, and to contribute to the internal and external visibility of the Department.
- Prepare proposals and applications to external bodies for funding.
- Use new research techniques and methods and extend the research portfolio.
- Demonstrate initiative and be proactive within his/her domain of responsibility.
- Independently provide advice and deal with queries to support junior staff.
- Conduct individual and collaborative research projects.
- Be aware of health and safety in the work environment.
- Undertake any other reasonable duties that may be relevant to the role outline.
- Be committed to his/her personal career development.
Skills, knowledge, and experience
- MBBS or equivalent
- Two or more years working as a junior doctor in a UK hospital
- Knowledge of neurology and neuroscience
- Experience of taking a neurological history and examination
- Experience of performing a fully informed consent procedure
- Experience of taking and handling blood samples
- Experience of performing a lumbar puncture and handling CSF samples
- Ability to work independently and in a team
- Motivated and enthusiastic
- Person and project management skills
- Conscientious and organised
- Have experience working on a neurological ward
- Knowledge of gene therapeutic strategies
- Long-term interest in conducting clinical research
- All employees are expected to adhere to King’s policies and procedures which are published on the HR webpages.
- Employees will be expected to comply with any reasonable request from a manager to undertake work of a similar level that is not specified in this job description.
- This post may be required to work irregular hours in accordance with the needs of the role.
- We plan to conduct interviews within 1-2 weeks of the application closing date.