KINGS COLLEGE LONDON

Postdoctoral Research Associate in Randall Centre for Cell and Molecular Biophysics

Location
London (Greater) (GB)
Salary
£39,345 - £42,652, including London Weighting Allowance
Posted
Wednesday, 30 June 2021
End of advertisement period
Wednesday, 4 August 2021
Ref
026485
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

Job description
Investigation on RNA binding properties of disordered unconventional RNA binding motifs   
 
Applications are invited for a postdoctoral scientist to investigate the mechanisms of RNA binding mediated by disordered regions lacking conventional RNA binding annotations in the laboratory of Professor Maria R (Sasi) Conte, Randall Centre for Cell and Molecular Biophysics, King’s College London.
 
ABOUT US
Our lab specialises in understanding the detailed mechanisms of interaction between proteins and RNA, with a major focus on the La-related proteins (LARPs). We use a combination of structural biology, biophysics and biochemistry techniques and work closely with interdisciplinary collaborators to test hypotheses in the context of cell biology and model organisms.   
 
WE ARE LOOKING FOR  
a skilled, motivated and enthusiastic postdoctoral candidate with a strong interest in protein-RNA interactions and biophysics. The project will focus on the LARPs involved as key regulators of gene expression via a variety of mechanisms. 
 
The successful applicant will find themselves working in a dynamic, interdisciplinary and exciting research environment and will be based in the Randall Centre on the Guy’s Campus, London, UK. The project will be supported by the state-of-the-art infrastructure of the Centre for Biomolecular Spectroscopy and the Randall Centre.
 
This is a new position funded by the Leverhulme Trust  and is available immediately
 
This post will be offered on a fixed-term contract for 12 months with possibility for further extension for a further 2 years.
This is a full-time post - 100% full time equivalent

REQUIREMENTS 

The successful candidate will have most of the following characteristics:  

• A Ph.D. degree in biophysics, biochemistry, structural biology or related field 

• Experience in NMR spectroscopy of proteins and/or RNA

• Demonstrated proficiency in a range of biophysical and structural biology techniques (e.g. CD, fluorescence spectroscopy, EMSA, titration calorimetry, mass spectrometry, SAXS, X-ray crystallography) 

• The ability to perform, interpret and integrate the results of biophysical and biochemical experiments 

• Proficiency in molecular biology and protein expression and purification

• The ability to adapt, develop and implement methods as dictated by the progress of the investigations

• Prior expertise in SAXS/SANS would be highly advantageous

• Experience in intrinsically disordered proteins would be a plus

• The capability to plan and execute experimental work without close supervision 

• The ability to work as part of a team

Applications will start to be evaluated on 4th August 2021 but the position will remain open until the job is filled, please contact Prof. Sasi Conte

There is no expectation that candidates have experience in all these fields, and training will be provided.

This is a new position funded by the Leverhulme Trust and is available immediately. 

This post will be offered on a fixed-term contract for 12 months with possibility for further extension for a further 2 years.

This is a full-time post - 100% full time equivalent.  

Contact details: Professor Sasi Conte, sasi.conte@kcl.ac.uk / +44 (0)20 7848 6194.

Similar jobs

Similar jobs