Research Associate, Department of Diabetes
- Employer
- KINGS COLLEGE LONDON
- Location
- London (Central), London (Greater) (GB)
- Salary
- £38,304 per annum, including London Weighting Allowance
- Closing date
- 25 May 2021
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- Academic Discipline
- Clinical, Pre-clinical & Health, Other Health & Social Care
- Job Type
- Research Related, Research Associate
- Contract Type
- Fixed Term
- Hours
- Full Time
Job Details
Applications are invited for the position of Post-Doctoral Research Assistant in the laboratory of Dr Paul Caton. The protein eNAMPT/visfatin plays an important role in the pathophysiology of NAFLD and NASH. The post-holder will focus on investigating the therapeutic potential of novel eNAMPT modulating compounds, using mouse models of NASH.
Minimum qualifications are a PhD with strong expertise in in vivo model systems and compound administration, plus experience of liver analysis. Experience in generation and analysis of in vivo models of NASH/NAFLD and or insulin resistance is desirable. Candidates should be highly motivated individuals with excellent communication skills and have the ability to work independently and as part of a team.
- PhD in a relevant biological sciences subject - Expertise in compound administration to in vivo model systems
- Experience of Liver histology, immunohistochemistry, FACs analysis - Knowledge and experience of generating and phenotyping mouse models of NASH/NAFLD, obesity, insulin resistance and type 2 diabetes
- Home Office Licence
This post will be offered on a fixed-term contract for 11 months.
This is a full-time post.
Key responsibilities
- Administration of compounds to in vivo NAFLD/NASH models
- Phenotyping of NASH/NAFLD models
- Supervision of MSc/BSc students where required
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
Essential criteria
- Compound administration to in vivo models (e.g. intravenous, oral gavage, sub-cutaneous, intra-peritoneal)
- Home Office animal license
- Experience of Liver histology, immunohistochemistry, FACs
- Generating and phenotyping mouse models of NASH/NAFLD
- Knowledge of NASH/NAFLD pathophysiology
- Willing and able to work in a team
- Ability to keep clear and well-organized laboratory notes and records
- Ability to plan and prioritise workload
- Ability to carry out known/learnt techniques unsupervised
- Good communication (both written and verbal) and presentation skills
- Self-motivated, ability to work independently
- PhD
Desirable criteria
- Experience of qPCR, western blotting, ELISA
- Knowledge of insulin resistance and CVD
- Experience of cardiovascular and adipose tissue analysis
- Liver cell isolation and culture
Company
King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.
King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.
King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.
King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.
King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.
- Mini-site
- KINGS COLLEGE LONDON
- Telephone
- +(44)02078365454
- Location
-
STRAND
LONDON
WC2R 2LS
United Kingdom
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