Research Associate in Randall Centre for Cell and Molecular Biophysics
A post-doctoral position is available in the Bergeron group in the Randall Centre for Cell and Molecular Biophysics at King's College London, to study the structure of protein complexes involved in bacterial motility and adherence, using a combination of cryo-EM, NMR, X-ray crystallography and other biophysics techniques. We are a small, recently-established group interested in the structure of bacterial nano-machines. The position is available for 18 months, and is funded by a BBSRC grant, ending 30th June 2022.
The ideal candidate will have (or be about to complete) a PhD in Biochemistry or Biophysics, with a strong background in protein structure determination (X-ray crystallography, cryo-EM and/or NMR). Experience in handling virulent bacteria (Salmonella, Campylobacter, etc¿) would be advantageous.
King's College London is equipped with state-of-the-art structural biology facilities, including access to the LonCEM Titan Krios cryo-EM with K3 direct-electron detector, an 800 MHz spectrometer, crystal screening robots etc.
This post will be offered on a fixed-term contract until 28th February 2023
This is a full-time post - 100% full time equivalent
- To co-ordinate and drive a research project investigating the structure and mechanism of protein complexes involved in bacterial motility.
- The candidate will plan and carry out experimental work, devise strategies for further development and advancement of the project, and s/he will be involved in compiling the data, and writing manuscripts.
- To contribute to the overall scientific endeavour of the research team and to take responsibility for areas of several of the current projects.
- Undertake any other reasonable duties that may be relevant to the role outline.
- To work in collaboration with other groups, within the UK and abroad, as required by the project.
- To attend workshops and conferences, and present obtained results in posters and/or oral presentations.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
1. Have a PhD in molecular biology, biochemistry, biophysics or equivalent
2. Expertise in protein purification
3. Experience in protein structure determination (X-ray crystallography, NMR and/or cryo-EM)
4. Excellent communication skills, both written and verbal
5. Willingness to contribute to all aspects of the lab, including supervising and mentoring students
6. Ability to work with collaborators
7. Willingness to travel for data collection, conferences
8. Ability to effectively manage time and conduct an independent research project
9. Ability to analyse and solve problems with an appreciation of longer-term implications
10. Ability to effectively manage time allocation between research activities, student supervision, laboratory administration and dissemination of research findings
11. Ability to adapt skill set to the changing requirements of the project
1. Experience with handling difficult proteins such as membrane proteins, glycosylated proteins etc
2. Have experience handling a range of bacterial strains, including in cat-2 environment (Salmonella, Campylobacter, pseudomonas)
*Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.
This post is subject to Occupational Health clearance.