Laboratory of Docent Daniela Ungureanu and Professor Jussi Taipale at the Medical Systems Biology group (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology ) at the Applied Tumour Genetic Program at University of Helsinki, Faculty of Medicine invites applications for the position of

POSTDOCTORAL RESEARCHER

Our research group is part of the Academy of Finland's Center of Excellence in Tumour Genetics Research. The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer. We are also working on pharmaco-genomic studies of drug resistance mechanisms in cancers such as ovarian cancer.

Applicants with a doctoral degree and strong background in molecular biology/bioinformatics who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English.

The appointment will be for 3 years starting upon agreement. Trial period of 6 months will be applied. The monthly gross salary will be appr. 3200-3500 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www.helsinki.fi/en/about-us/careers.

For additional information about the position, please contact Dr. Daniela Ungureanu: daniela.ungureanu@helsinki.fi. For additional information about the application process, please contact HR Specialist Päivi Sinisalo: paivi.sinisalo@helsinki.fi.

Please submit your application as a single PDF file containing your CV, publication list including impact factors and two letters of reference through the University’s electronic recruitment system by clicking “Apply for the position” link below. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal, under the tab “Career and Job”. If you have questions about the recruitment system, please contact rekrytointi@helsinki.fi.

The deadline for applications is 30 April 2021.

Selected publications from Taipale lab:

Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.

Yin et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 2017, May 5;356(6337).

Nitta et al. Conservation of transcription factor binding specificities across 600 million years of bilateria evolution. Elife. 2015 Mar 17;4.

Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep 7, 654–60.

Yan et al. (2013) Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 154, 801-13.

The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The Faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of medical education.

The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.

Due date

30.04.2021 23:59 EEST