University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Job Description

The Research Investigator Sr (SRI) will act in a leadership role, overseeing and designing advanced experiments. He/She will assist the Principal Investigator and play a leading role in developing a research program in the advancement of specific area of study and will play a crucial role both in all aspects of research products including development, implementation, and data analysis. In the development stage, the SRI will assess proposed projects by conducting feasibility studies to provide valuable input regarding viability, efficiency, timeline, and study design. In the implementation stage, he/she will supervise and perform the project. This includes overseeing workflow and productivity of lab personnel and providing training to them on specific techniques as necessary. Finally, the SRI will be responsible for data analysis, preparation of manuscripts, and presenting research findings through various forums. Senior Research Investigator must demonstrate the ability to analyze and present data in professional "publication ready" format and to be able to independently prepare manuscripts and grant writings for submission.

The person holding this position will direct and oversee projects exploring the role of type I interferons in HIV, SIV and SHIV natural history. The person should have at least 5-10 years of experience in standard molecular biology techniques, HIV/SIV/SHIV virus isolation, human and non-human primate primary cells tissue culture, and a broad knowledge of innate and adaptive immunity, in particular of type I interferons. The person should be familiar with HIV/SIV/SHIV culture under BSL2/3 containment condition, be able to perform viral neutralization assays in primary and reporter cell-lines, clone full-length replication competent genomes of HIV/SIV/SHIV, perform site-directed mutagenesis, and analyze next generating sequencing data. Proficiency in DNA/RNA extraction, PCR protocols including Single Genome Amplification, and next generation sequencing library preparation is required.

Job Qualifications:

Ph.D., MD or equivalent doctoral degree and 5 years of experience required.

Position contingent upon funding.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$35,568.00 - $204,000.00

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.