Senior Research Associate - Faculty of Medicine

Toronto (City), Ontario (CA)
Wednesday, 25 November 2020
End of advertisement period
Wednesday, 2 December 2020
Contract Type
Fixed Term
Full Time

Senior Research Assoc
Date Posted: 11/24/2020
Req ID: 1948
Faculty/Division: Faculty of Medicine 
Department: Donnelly Centre
Campus: St. George (Downtown Toronto)


The Donnelly Centre in the Temerty Faculty of Medicine, University of Toronto invites applications for the position of Senior Research Associate to lead the design, development and validation of a novel set of small-domain phage libraries and to direct the computational biology in the laboratory of Dr. Sachdev Sidhu. The incumbent will work as part of a dynamic team with both internal and external collaborators to discover and characterize therapeutic candidates designed to target membrane proteins involved in several diseases.

The successful candidate must have a Ph.D. in a relevant scientific field and 5 years of experience as a research associate. The candidate must be familiar with and have a strong skill set in computational analysis, biochemistry, structural biology, high‐throughput biochemical analyses, expression and purification of recombinant proteins, and protein biophysical characterization. Experience with rational protein engineering, directed evolution and next generation sequencing (NGS) is essential. The candidate will be experienced in the ubiquitin pathway and using phage display methods to develop inhibitors of ubiquitin-associated enzymes. The candidate will also have an excellent publication record, and be able to prepare manuscripts for submissions to peer‐review publications/journals. Experience presenting findings is required. The ideal candidate will be able to work independently, but also collaboratively with other members of the lab and individuals from partnering institutions. Experience providing direction to junior researchers is also necessary.

Key Responsibilities:

  • Lead a small team of computational biologists to assist the laboratory on the analysis of NGS sequencing data from phage display selections to identify trends and patterns and interpret the results.  The candidate will be responsible of the generation of advanced analysis of our database of biologics to extract new knowledge and to bring disruptive insights
  • Design rational protein engineering projects towards developing a set of novel high-affinity reagents and therapeutic leads to treat several diseases
  • Perform expression and purification of recombinant proteins and characterize these molecules using standard biophysical/biochemical methodologies
  • Work efficiently in multi‐disciplinary, multi‐institutional teams
  • Co‐ordinate with other project leaders, PIs and collaborators
  • Conduct data analysis and report findings in a clear manner
  • Present research findings to Principal Investigators and other members of the research team, as well as at local, national and international conferences
  • Communicate key findings to collaborators in both academic and industrial partnerships

Beyond these responsibilities, the individual will be expected to participate in the preparation of grant applications and research supervision of one or more students or other trainees. At all times, the individual is expected to support the overall research and teaching missions of the lab. 

The candidate will be expected to perform research with a high degree of independence and will design, direct, execute, analyze and present in written and oral forms novel investigative studies that build on and/or take advantage of the resources and expertise within the lab as well as candidate’s academic expertise.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, members of sexual minority groups, and others who may contribute to further diversification of ideas. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

Closing Date: 12/02/2020, 11:59PM EDT
Employee Group: Research Associate
Appointment Type: Grant - Continuing
Schedule: Full-Time
Pay Scale Group & Hiring Zone: R02 -- Sr. Research Associates $53,224 - $92,965 - $108042 (open)
Job Category: Research Administration & Teaching

All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

Diversity Statement
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see

Accessibility Statement 
The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission.

The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities.

If you require any accommodations at any point during the application and hiring process, please contact
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.