This position is for a talented and enthusiastic postdoctoral molecular/cell biologist or physiologist to work on a BHF Programme Grant on Redox-regulated adaptive pathways in heart failure. The project will involve the use of iPSC-derived cardiomyocytes and “engineered heart muscle (EHM)” as model systems to investigate biological mechanisms. We therefore seek to appoint an individual with a strong background in cell and molecular biology (rather than tissue engineering), e.g.cloning, viral transduction, CrispR/Cas9 approaches, immunoblotting, microscopy of tissue sections. Previous experience with iPSC-derived cardiomyocytes or EHM is highly desirable. Experience with muscle force measurements and/or the use of in vivo models of disease would be helpful.
The postholder will be part of a multi-disciplinary research grouping working on several different aspects of cardiovascular pathophysiology, with access to state-of-the-art laboratory facilities within the King’s BHF Centre of Research Excellence.
- Develop and undertake research of high quality consistent with making a full active research contribution in line Department/Division/School research strategy
- Manage specific pieces of activity to an agreed timeline and within a specific budget including literature reviews, data collection and analysis, report writing.
- Attend and, as appropriate, present research findings and papers at internal academic meetings and external professional conferences, and to contribute to the internal and external visibility of the department.
- Work as a conscientious and committed member of the team in order to achieve the aims of the projects and the primary care group.
- Facilitate collaboration and networking which engages and supports the activities of the project
- Participate in educational activities as appropriate to the stage of your career.
- To be committed to your own personal career development.
- Liaise with the administrative team for the support of the project
- Contribute to publications arising from this project
- Undertake any other reasonable duties that may be relevant to the role outline.
Communication & Networking:
- Deal with routine communication using a range of media
- Communicate complex information orally and in writing
- Communicate material of a specialist or highly technical nature
- Liaise with colleagues and students
- Build internal contacts and participate in internal networks for the exchange of information and to form relationships for future collaboration
- Join external networks to share information and identify potential sources of funds
Decision Making, Planning and Problem Solving:
- Use new research techniques and methods
- Identify areas for research, develop new research methods and extend the research portfolio
- Contribute to collaborative decision making with colleagues in area of research
- Respond to requests for information in accordance with College policies
- Provide advice with respect to own areas of expertise
- Set the standards of service and ensure overall quality is maintained
Analysis & Research:
- Develop research objectives and proposals for own or joint research, with the assistance of a mentor
- Conduct individual and collaborative research projects
- Write up research work for publication
- Maintain knowledge, expertise and awareness of relevant research literature by self-directed enquiry and continuing education
- Translate knowledge of advances in the area of expertise into research activity
- Analyse and interpret research data and draw conclusions on the outcomes
Teamwork, Teaching & Learning Support:
- Work with colleagues on joint projects as required
- Collaborate with academic colleagues on areas of shared research interest
- Attend and contribute to relevant meetings
- Contribution to the supervision or training of more junior staff and students as necessary
- Contribution to laboratory maintenance and administration.
- Show consideration to others
Skills, knowledge, and experience
- PhD in a relevant biological sciences project
- Strong background in cell/molecular biology
- Good written presentation skills, communication skills (written & verbal), and good IT skills
- Broad molecular biology research experience (e.g. cloning, RT-PCR)
- Broad cell biology experience, e.g. immunoblotting, primary cell culture, confocal microscopy, immunofluorescence
- Successful completion of research projects (published papers in high Impact Factor journals)
- Self-motivated, able to work independently, as well as willing and able to work as part of a team
- Commitment to continuing personal and professional development,
- Able to carry out know/learnt techniques unsupervised, and flexible/able to change in current professional context
- Able to plan and prioritise workload and keep clear and well-organised laboratory notes and records
- Background in cardiovascular biology
- Experience of working with iPS-derived cardiomyocytes or engineered heart muscle
- Experience of working with in-vivo models of disease or gene-modification
This advertisement does meet the requirements for a Certificate of Sponsorship under Home Office regulations and therefore the university will be able to offer sponsorship for this role.