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Bioinformatician/Computational Biologist

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater) (GB)
Salary
£38,304 to £43,822 including London Weighting Allowance
Closing date
27 Aug 2020

Job Details

In collaboration with a major pharmaceutical partner, King’s College London is launching a substantial programme of basic and translational research into understanding the early molecular and immunological events that lead to the establishment Clonal Haemopoiesis and early stages of Myelodysplastic Syndrome (MDS). Comparison of these early events with subsequent molecular phenotypes of MDS and Acute Myeloid Leukaemia (AML) should help to identify targets for therapeutic intervention. It is anticipated we will recruit over 6,000 patients undergoing hip replacements as a healthy ageing cohort for the study to follow for at least 5 years; continuing to observe changes to health and haematology profiles. The programme aims to build one of the largest Biobanks to interrogate associations between immune and genetic changes in the blood and diseases that increase in prevalence with age and to enable future translational research endeavours. There is therefore an urgent need to develop reliable tools for patient stratification in order to ensure that only those likely to benefit are given a specific treatment.    

The post holder will contribute expertise in applying technologies of all types associated with the stratification of patients for immune-oncology treatments. As part of this job, the post holder will contribute in designing a major database, developing pipelines to analyse and integrate multiple biological research and clinical data streams, and generating insights that drive the elucidation of key disease mechanisms. The project involves (and not limited to) multi-omic (Genomics, single-cell RNAseq, ChIP-seq, Methyl-seq, metabolomics, and microbiomics) and mass-cytometry (CyTOF) data analysis of blood samples.       

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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