Postdoctoral Research Associate
Applications are invited for a postdoctoral researcher position funded by the Wellcome Trust.
The successful applicant will pursue a research project with the goal of understanding how brain-wide neural circuits lead to flexible cognitive behaviours in mice. The techniques employed will include chronic in-vivo two photon calcium imaging of multiple cell classes, targeted optogenetic manipulations, viral vector based functional circuit mapping, and quantitative mouse behaviour.
The successful applicant will benefit from the collaborative culture of the Centre for Developmental Neurobiology at King's College London and will have the opportunity to develop collaborations with groups studying animal models of brain disorders.
Candidates must have a strong research track record. Experience with in-vivo two photon imaging, rodent behaviour and analysis of complex datasets will be highly valued. Candidates with programming skills are encouraged to apply.
This is a full time fixed-term position until 31 May 2023.
- Train mice to perform flexible, cognitive behaviours
- Perform chronic two-photon imaging in behaving mice
- Use viral injections to label distinct cell types based on projection target or molecular class
- Perform optogenetic and chemo genetic manipulations of cells during behavior and during imaging
- Perform post-hoc immunostaining and confocal imaging
- Perform image processing and computational analysis of data from experiments in the lab
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, Knowledge and Experience
- PhD in Neuroscience or related discipline (or close to completion)
- Experience in addressing neural circuit-level questions
- Strong publication record
- Knowledge of and familiarity with imaging methods
- Intermediate programming and statistics skills using Matlab/Python/R or similar.
- Experience in trouble-shooting problems with laboratory equipment
- Ability to learn new skills and techniques
- Ability to communicate findings and to write scientific reports
- Experience with rodent behaviour
- Advanced quantitative analysis skills, particularly of imaging and behavioural datasets
- Stereotactic injections of viral vectors (AAVs, CTB, CAV2, modified-rabies etc.)
This post is subject to Disclosure and Barring Service and Occupational Health clearance.
This advertisement does meet the requirements for a Certificate of Sponsorship under Home Office regulations and therefore the university will be able to offer sponsorship for this role.