Job number ACAD104604
Division/School School of Cellular and Molecular Medicine
Contract type Open Ended
Working pattern Full time
Salary £33,797 - £38,017 per annum
Closing date for applications 02-Aug-2020
We are looking for a highly motivated, intellectually curious and creative postdoctoral research fellow/ research associate with a strong interest in tissue maintenance, regeneration and ageing to join our lab.
The Patel lab at the School of Cellular and Molecular Medicine, University of Bristol studies how tissues regenerate themselves after damage and how they maintain themselves over time. Reactive oxygen species (ROS) play an important role in regeneration in multiple contexts, including local tissue repair, limb regeneration and nerve regeneration. Nevertheless, we still don’t fully understand how ROS promote regeneration. The Patel lab uses the adult Drosophila intestine to better understand this process. Upon damage to the fly intestinal epithelium, intestinal epithelial cells produce ROS and activate stress signalling that promote stem cell-mediated regeneration, partly via p38 stress signalling (Patel et al., 2019, Nature Communications). Using loss- and gain-of-function Drosophila genetics, proteomics and transcriptomics, the research associate will investigate how ROS promote intestinal regeneration by identifying ROS-controlled regulators of regeneration and by determining the molecular responses to ROS and stress signalling. This work will have far-reaching impact on our understanding of regeneration in many contexts and may help develop therapies for tissue regeneration, inflammatory diseases and cancer.
Our lab is generously funded by the Wellcome Trust and you will have access to top-notch core facilities (e.g. proteomics, transcriptomics and imaging) for your work, travel funds to attend conferences and access to staff development courses.
You will have an undergraduate degree and PhD (awarded or soon to be awarded) in Life Sciences, or in a related subject. Prior experience with Drosophila genetics, molecular biology, microscopy, proteomics, transcriptomics, flow cytometry or bioinformatics is a plus, but is not essential.
Please include the following in your application cover letter (2 pages max): a) description of your most important research contributions, b) why you think your research is important and what impact it has had and c) your research interests and career aspirations.
The full-time position is available from 15.08.20 and will be for 2 years in the first instance with the possibility of extension.
Non-UK candidates will be provided a guaranteed endorsement to apply for a high priority UK visa. Information about reimbursement of immigration and relocation costs can be found at: http://www.bristol.ac.uk/jobs/relocation-support.
We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.