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Postdoctoral Research Associate in Cardiovascular Sciences

Employer
KINGS COLLEGE LONDON
Location
London (South), London (Greater) (GB)
Salary
Grade 6, £38,304 to £42,652 per annum inclusive of London Allowance
Closing date
19 Nov 2019

Job Details

The post holder will report to Professor Catherine Shanahan and will perform research investigating the epigenetic regulation of vascular smooth muscle cell (VSMC) calcification.  We have identified a bromodomain (Brd) chromatin remodeling protein as a key regulator of vascular calcification.

This project will identify Brd regulated genes, confirm whether the role of Brd in calcification is through the chromatin remodelling BAF complex and determine the changes in histone acetylation that direct Brd: DNA interactions. We will test the efficacy of novel small molecule inhibitors in preventing calcification both in a novel organoid model and in vivo.

The candidate should have experience in molecular biology, epigenetics and data analysis and a keen interest in multidisciplinary research.  Experience in bioinformatics is highly desirable. The successful candidate will join a research group within the BHF Centre of Research Excellence which provides an excellent highly multidisciplinary environment with state-of-the-art equipment and facilities.

Candidates should have, or be about to obtain a PhD in Biological Sciences or a related discipline.

This post will be offered on a fixed-term contract until 31 December 2022

The selection process will include a panel interview.

For an informal discussion to find out more about the role please contact Professor Catherine Shanahan cathy.shanahan@kcl.ac.uk

To apply, please register with the King’s College London application portal and complete your application online.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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