Division/School School of Biochemistry
Contract type Open Ended
Working pattern Full time
Salary £33,797 - £38,017 per annum
Closing date for applications 20-Oct-2019 

We are looking for a self-motivated and talented scientist to study the role of altered microRNA activity on dendritic spine morphology and synaptic function in mouse models for Alzheimer’s disease. The project will build on our recent discovery that Argonaute 2 (Ago2) phosphorylation regulates the local translation of specific mRNAs and is required for structural and functional plasticity (Rajgor et al., EMBO Journal 2018).

The work will be based initially in the laboratory of Jon Brown in Exeter for in vivo molecular interventions (adenovirus and antagomir injections) and ex vivo slice electrophysiology. This will be followed by biochemical and cell imaging techniques in Jonathan Hanley’s lab in Bristol.

Applicants must have a relevant postgraduate research degree or equivalent professional qualification/experience or be working towards one, with relevant lab experience, and at least one article published in a quality peer-reviewed journal.

For informal enquiries please contact: Jonathan Hanley, +44(0)117 3311944, jon.hanley@bristol.ac.uk or Jon Brown, +44(0)1392 725504, J.T.Brown@exeter.ac.uk.

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.