Postdoctoral Research Associate
The groups of Dr Marc-David Ruepp and Dr Sarah Mizielinska are seeking a Postdoctoral Research Associate to carry out a joint project to identify converging minor intron splicing defects in amyotrophic lateral sclerosis (ALS) and elucidation of their therapeutic potential (funded by the Motor Neuron Disease Association). This project will involve generating novel C9orf72 knock-in human stem cell lines using CRISPR/Cas9 genome editing followed by phenotypic and transcriptomic analysis of IPSC-derived motor neurons to identify novel targets of interest to neurodegeneration.
We are looking for a motivated and dedicated candidate with good knowledge in RNA biology and mammalian cell culture, ideally stem cell culture and neuronal differentiation.
This position will work between two very collaborative research groups who are both based within the UK Dementia Research Institute (DRI) centre that is embedded within the Department of Basic and Clinical Neuroscience at King’s College London (www.kcl.ac.uk/ioppn/depts/bcn/dri/lab-groups). The DRI is a national consortium focused on cutting-edge dementia research funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK (www.ukdri.co.uk).
This post will be offered on a fixed-term contract for 3 years or until 30 November 2022.
This is a full-time post - 100% full time equivalent.
The selection process will include a panel interview, a presentation.