Postdoctoral Research Associate
Application closing date 14/01/2019
Faculty / School or Service Faculty of Health and Life Sciences
Salary £32,243 - £40,802 per annum
Package As one of Coventry's biggest employers, we offer some pretty impressive benefits including an excellent pension scheme and generous holiday allowances.
Job category/type Research
This is an exciting and highly collaborative research project funded by a BBSRC-Industrial Partner Award that benefits from close collaboration between internationally-recognised researchers at the neighbouring institutions of Coventry University (Prof M Wheatley), Aston University (Prof D Poyner) and University of Birmingham (Prof T Dafforn) plus the multi-national Pharma company UCB.
We pioneered detergent-free purification of functionally-stable G-protein-coupled receptors(GPCRs) using styrene maleic acid lipid particles (SMALPs) that preserve the nano-scale native lipid environment throughout purification. This project will use nanobodies (single domain VHH antibodies) recognising family B GPCRs themselves and coupled to accessory proteins, generated using our SMALP technologies in conjunction with the expertise of our industrial partner UCB, to investigate family B GPCR and RAMP interaction in both recombinant cellular systems and in human tissue samples. The pharmacological properties of nanobodies generated will also be characterised.
We aim to recruit an enthusiastic and skilled Post-Doctoral Researcher, collaborative in outlook, who will drive this ambitious programme forward. Applicants should have a PhD in molecular pharmacology, biochemistry or a related subject. Ideally, they will already have Post-Doc experience and a background in GPCR molecular pharmacology but these are not essential.
The successful applicant will join the group of Prof Mark Wheatley in the purpose-built research laboratories of the Centre for Sports, Exercise & Life Sciences (CSELS), Coventry University and will also work in the neighbouring laboratories of Prof Poyner and Prof Dafforn plus UCB, as appropriate. This multi-disciplinary project spanning academic institutions and industry will provide the appointed researcher with an exciting project and an impressive skill-base for future career progression.
Interviews will take place on Wednesday 30th January 2019.